LAUSR

Schisandra chinensis lignans are the main active components of traditional Chinese medicine Schisandra chinensis in East Asia. At present, there are more and more medicines and health foods in which the total Schisandra chinensis lignans extracts are considered as the main active components, but little research has been done on the active components of Schisandra chinensis lignans in blood and main target organs. In this study, the components of Schisandra chinensis lignans in the blood, liver and brain tissues of rats at different time points after the intragastrical administration of Schisandra chinensis lignans were determined by a metabolomic method based on HPLC with quadrupole time-of-flight MS/MS spectrometry. Twelve Schisandra chinensis lignans and 15 metabolites in the blood, liver and brain of rats were identified. The results showed that the main metabolic ways of Schisandra chinensis lignans in rats were hydroxylation, demethylation and demethylation-hydroxylation, and some of them might undergo demethylation, dehydrogenation, epoxidation and elimination reaction. The time-dose characteristics of Schisandra chinensis lignans and their metabolites in the blood and target organs were analyzed, which may be helpful to elucidate the active substances that really exert the pharmacodynamic effects of Schisandra chinensis lignans in organisms. This article is protected by copyright. All rights reserved.