LAUSR

In this work, various types of metal-organic frameworks were synthesized, and their affinities towards buprenorphine were evaluated using dispersive solid-phase extraction. The extracted buprenorphine was determined by ultra-performance liquid chromatography-ultraviolet detection system. The highest extraction recovery was observed by employing zeolitic imidazole framework-67. Then, a facile and fast extraction method was designed for the extraction and purification of the target drug. Optimization of the extraction method was carried out by the design of experiment approach. A linearity range of 1-1000 μg L-1 with the limit of detection of 0.15 μg L-1 and relative standard deviations (50 μg L-1 , n = 5) of 3.4% was obtained for standard sample analysis. Under optimized experimental and instrumental conditions, the relative recoveries were in the range of 95 to 111%. Eventually, zeolitic imidazole framework-67 was successfully employed for the extraction and determination of buprenorphine in the biological fluids with satisfactory results. This article is protected by copyright. All rights reserved.