LAUSR

A modified [Quick, Easy, Cheap, Effective, Rugged and Safe] method was established for simultaneous determination of atropine, anisodamine and scopolamine in Goji berries via ultra high performance liquid chromatography tandem mass spectrometry. The graphene/hexagonal boron nitride hybrids was prepared and firstly applied as a cleanup adsorbent. Compared to classical cleanup adsorbent (C18 ), the graphene/hexagonal boron nitride hybrids as adsorbent had better extraction efficiency for the detection of analytes. Under the optimal conditions, the proposed analytical method achieved satisfactory linearity (R2 >0.995), and obtained desirable recoveries ranged from 77.4 to 94.0% with the relative standard deviation of 1.2-6.1% at the concentration levels of 3.2-13.4 μg kg-1 . The limits of quantitation of atropine, anisodamine and scopolamine were respectively 3.2, 4.6, 4.5 μg kg-1 with linearity ranged from 3.2-25.4 μg kg-1 . The modified [Quick, Easy, Cheap, Effective, Rugged and Safe]-ultra high performance liquid chromatography tandem mass spectrometry method was successfully applied to evaluate the safety of Goji berries collected from 30 plant areas in China, suggesting its applicability and suitability for the routine analysis of three tropane alkaloids in Goji berries. This article is protected by copyright. All rights reserved.