Photo by hakannural from unsplash
Adverse drug reactions of Traditional Chinese medicine injection mainly manifested as pseudo-allergic reactions. In the present study, ginsenoside Rd, Ro and Rg3 were identified as pseudo-allergic components in Shengmai Injection… Click to show full abstract
Adverse drug reactions of Traditional Chinese medicine injection mainly manifested as pseudo-allergic reactions. In the present study, ginsenoside Rd, Ro and Rg3 were identified as pseudo-allergic components in Shengmai Injection by a high-expression Mas-related G protein coupled receptor X2 cell membrane chromatography coupled online with high-performance liquid chromatography and mass spectrometry. Their pseudo-allergic activities were evaluated by in vitro and in vivo assay. The three compounds were further found to induce pseudo-allergic reaction through Mas-related G protein coupled receptor X2. Therefore, we concluded that ginsenoside Rd, Ro and Rg3 may be potential allergens cause pseudo-allergic reactions. This study might be helpful for the safe use of Shengmai Injection. This article is protected by copyright. All rights reserved.
Journal Title: Journal of separation science
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!