LAUSR

In this work, a magnetic octahedral metal organic framework (Fe3 O4 @NH2 -MIL-101(Fe)) was synthesized for the magnetic solid phase extraction of three anthraquinones, including aloe-emodin, emodin, and physcion, in rhubarb. The Fe3 O4 @NH2 -MIL-101(Fe) exhibited a high specific surface area of 259.2 m2 /g with an average pore size of 6.0 nm and a high magnetic responsivity of 23.4 emu/g, which may be used as an adsorbent for rapid preconcentration and separation of target analytes. The main parameters for magnetic solid phase extraction of anthraquinones, including the amount of adsorbent, extraction time, extraction temperature, extraction pH, elution solvent, and elution time, were systematically optimized. The whole extraction process required a very low amount of adsorbent and a small volume of the sample. Besides, under the optimized conditions, the method showed satisfactory spiked recovery for anthraquinones in the range of 93.3%-109.1%, and the LODs were 1.7-3.4 ng/mL. The RSDs for intra- and inter- day precision were 0.2%-1.3% and 0.2%-0.6%, respectively. The experimental results indicate that the developed method is feasible for the analysis of anthraquinones in rhubarb. This article is protected by copyright. All rights reserved.