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Chronic otitis media (COM) is characterized by middle ear fluid predominantly containing cytokines, Nontypeable haemophilus influenzae (NTHi), the mucin MUC5B, and neutrophil extracellular traps (NETs). NETs consist of extracellular DNA… Click to show full abstract
Chronic otitis media (COM) is characterized by middle ear fluid predominantly containing cytokines, Nontypeable haemophilus influenzae (NTHi), the mucin MUC5B, and neutrophil extracellular traps (NETs). NETs consist of extracellular DNA coated with antibacterial proteins such as myeloperoxidase (MPO) and citrullinated histone 3 (CitH3). NETs can damage tissues and sustain inflammation. Our study aimed to develop an in vitro model of NETosis, testing COM inductors.
Keywords:
muc5b induces;
neutrophil extracellular;
otitis media;
extracellular trap;
vitro neutrophil;
induces vitro
Journal Title: Laryngoscope Investigative Otolaryngology
Year Published: 2020
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Journal Title: Laryngoscope Investigative Otolaryngology
Year Published: 2020
Link to full text (if available)
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recommendations!