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Biobanked tracheal basal cells retain the capacity to differentiate

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While airway epithelial biorepositories have established roles in the study of bronchial progenitor stem (basal) cells, the utility of a bank of tracheal basal cells from pediatric patients, who have… Click to show full abstract

While airway epithelial biorepositories have established roles in the study of bronchial progenitor stem (basal) cells, the utility of a bank of tracheal basal cells from pediatric patients, who have or are suspected of having an airway disease, has not been established. In vitro study of these cells can enhance options for tracheal restoration, graft design, and disease modeling. Development of a functional epithelium in these settings is a key measure. The aim of this study was the creation a tracheal basal cell biorepository and assessment of recovered cells.

Keywords: basal cells; retain capacity; tracheal basal; biobanked tracheal; basal; cells retain

Journal Title: Laryngoscope Investigative Otolaryngology
Year Published: 2022

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