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Interstitial photodynamic therapy and glioblastoma: Light fractionation in a preclinical model

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Glioblastoma is a high‐grade cerebral tumor with local recurrence and poor outcome. Photodynamic therapy (PDT) is a localized treatment based on the light activation of a photosensitizer (PS) in the… Click to show full abstract

Glioblastoma is a high‐grade cerebral tumor with local recurrence and poor outcome. Photodynamic therapy (PDT) is a localized treatment based on the light activation of a photosensitizer (PS) in the presence of oxygen, which results in the formation of cytotoxic species. The delivery of fractionated light may enhance treatment efficacy by reoxygenating tissues.

Keywords: photodynamic therapy; glioblastoma; interstitial photodynamic; glioblastoma light; therapy glioblastoma

Journal Title: Lasers in Surgery and Medicine
Year Published: 2017

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