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Laser‐induced thermal coagulation enhances skin uptake of topically applied compounds

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Ablative fractional laser (AFL) generates microchannels in skin surrounded by a zone of thermally altered tissue, termed the coagulation zone (CZ). The thickness of CZ varies according to applied wavelength… Click to show full abstract

Ablative fractional laser (AFL) generates microchannels in skin surrounded by a zone of thermally altered tissue, termed the coagulation zone (CZ). The thickness of CZ varies according to applied wavelength and laser settings. It is well‐known that AFL channels facilitate uptake of topically applied compounds, but the importance of CZ is unknown.

Keywords: coagulation; uptake topically; topically applied; induced thermal; applied compounds; laser induced

Journal Title: Lasers in Surgery and Medicine
Year Published: 2017

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