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Decreased phototoxicity of photodynamic therapy by Cx32/Cx26‐composed GJIC: A “Good Samaritan” effect

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Photodynamic therapy (PDT) has been widely used to treat malignant tumors. Our previous studies indicated that connexin (Cx) 32‐ and Cx26‐composed gap junctional intercellular communication (GJIC) could improve the phototoxicity… Click to show full abstract

Photodynamic therapy (PDT) has been widely used to treat malignant tumors. Our previous studies indicated that connexin (Cx) 32‐ and Cx26‐composed gap junctional intercellular communication (GJIC) could improve the phototoxicity of PDT. However, the role of heterotypic Cx32/Cx26‐formed GJIC in PDT phototoxicity is still unknown. Thus, the present study was aimed to investigate the effect of Cx32/Cx26‐formed GJIC on PDT efficacy.

Keywords: cx26 composed; photodynamic therapy; cx32 cx26; cx26; phototoxicity

Journal Title: Lasers in Surgery and Medicine
Year Published: 2019

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