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Experimental determination of shear stresses on an artificial transcoelomic metastasis model using optical tweezers: A comparison with numerical simulation

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One of the reported pathways of cancer spread is the transcoelomic pathway, which is understood as the spread of cancer cells in the abdominal and thoracic cavities through interstitial fluid.… Click to show full abstract

One of the reported pathways of cancer spread is the transcoelomic pathway, which is understood as the spread of cancer cells in the abdominal and thoracic cavities through interstitial fluid. It has been proven that the shear stresses caused by microfluidic currents on cancer tumors in the abdominal and thoracic cavities cause the detachment of cancer cells triggering transcoelomic metastasis; however, the magnitude of shear stresses has not yet been measured experimentally.

Keywords: transcoelomic metastasis; determination shear; shear stresses; cancer; experimental determination

Journal Title: Lasers in Surgery and Medicine
Year Published: 2022

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