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Histopathological evaluation of the R134a multipulsed spray cooling assisted 1210 nm laser lipolysis by the murine model in vivo

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Owing to the greater absorption affinity for lipo‐rich tissue than water, the 1210 nm laser is a promising candidate for transcutaneous lipolysis in the near‐infrared band. However, fat reduction is limited… Click to show full abstract

Owing to the greater absorption affinity for lipo‐rich tissue than water, the 1210 nm laser is a promising candidate for transcutaneous lipolysis in the near‐infrared band. However, fat reduction is limited because laser therapy may yield thermal injury of normal tissue. A new protocol to incorporate multipulsed cryogen spray cooling is beneficial to improve the lipolysis effect, and the parameters of laser and cooling can be optimized via skin histopathological analysis.

Keywords: spray cooling; histopathological evaluation; 1210 laser; lipolysis

Journal Title: Lasers in Surgery and Medicine
Year Published: 2022

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