Melasma is a refractory skin disease due to its complex pathogenesis and difficult treatment. Studies have found that human umbilical cord mesenchymal stem cell‐derived exosomes (hUCMSC‐Exos) could serve as a… Click to show full abstract
Melasma is a refractory skin disease due to its complex pathogenesis and difficult treatment. Studies have found that human umbilical cord mesenchymal stem cell‐derived exosomes (hUCMSC‐Exos) could serve as a novel cell‐free therapeutic strategy in regenerative and esthetic medicine. It could potentially treat melasma, but the skin barrier is a challenge. In this study, we aim to explore the safety and efficacy of hUCMSC‐Exos in the treatment of melasma and the means to promote its percutaneous penetration.
               
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