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Laser-assisted drug delivery of synthetic alpha melanocyte stimulating hormone and L-tyrosine leads to increased pigmentation area and expression of melanogenesis genes in a porcine hypertrophic scar model.

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One symptom of hypertrophic scar (HTS) that can develop after burn injury is dyschromia with hyper‐ and hypopigmentation. There are limited treatments for these conditions. Previously, we showed there is… Click to show full abstract

One symptom of hypertrophic scar (HTS) that can develop after burn injury is dyschromia with hyper‐ and hypopigmentation. There are limited treatments for these conditions. Previously, we showed there is no expression of alpha melanocyte stimulating hormone (α‐MSH) in hypopigmented scars, and if these melanocytes are treated with synthetic α‐MSH in vitro, they respond by repigmenting. The current study tested the same hypothesis in the in vivo environment using laser‐assisted drug delivery (LADD).

Keywords: assisted drug; hypertrophic scar; alpha melanocyte; stimulating hormone; melanocyte stimulating; laser assisted

Journal Title: Lasers in surgery and medicine
Year Published: 2023

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