LAUSR

Since the seminal experience of Starzl et al (1), liver transplant (LT) has been performed for Wilson's disease patients with failing livers and more controversially for neurologic disease. The majority of patients transplanted for Wilson's disease in a registry from the United States (2) and in a report from France (3) were adults with end-stage liver disease and its complications. These series each included pediatric patients where there was a marked increase in patients with acute liver failure due to Wilson's disease. Overall, LT outcomes are excellent for Wilson's disease patients. These reasons include especially in pediatric recipients a low frequency of hepatocellular carcinoma and a lack of comorbid conditions. The "era effect" of more recent improved outcomes reflects better surgical technique and the evolution of immunosuppressive management. This article is protected by copyright. All rights reserved.