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Oral Contraceptive–Induced Hepatic Sinusoidal Dilatation and Potential Implications for Living Donor Liver Transplantation: A Reason for Nonuse of Right Lobe Grafts

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Adult-to-adult living donor liver transplantation is being increasingly performed throughout the United States. To ensure safety, donors typically have to be young, healthy, and without significant comorbidities. Oral contraceptives are… Click to show full abstract

Adult-to-adult living donor liver transplantation is being increasingly performed throughout the United States. To ensure safety, donors typically have to be young, healthy, and without significant comorbidities. Oral contraceptives are some of the most commonly prescribed medications for young women and have been associated with a variety of liver complications with clear consequences, including intrahepatic cholestasis, hepatic and portal vein thrombosis, and hepatic adenomas. What is of less clear clinical significance, however, is the presence of sinusoidal dilation on liver biopsy, which has been associated with oral contraceptives in a variety of case reports and case series.

Keywords: contraceptive induced; oral contraceptive; transplantation; liver transplantation; donor liver; living donor

Journal Title: Liver Transplantation
Year Published: 2020

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