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The Current Landscape of Liver Transplantation After Ex Situ Machine Perfusion and Normothermic Regional Perfusion in the United States

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In the United States, there remains a discrepancy between the number of liver transplantation (LT) candidates awaiting transplantation and the availability of donor organs. To help address this discrepancy, the… Click to show full abstract

In the United States, there remains a discrepancy between the number of liver transplantation (LT) candidates awaiting transplantation and the availability of donor organs. To help address this discrepancy, the transplantation community has continued to pursue extended criteria donors. In particular, the number of donation after circulatory death (DCD) LTs performed annually in the Unites States has continued to grow. In response to these developments, there has been an interest in innovative technologies such as ex situ machine perfusion and in situ normothermic regional perfusion (NRP) as potential mechanisms to help safely expand the utilization of donated organs. This study aimed to examine the utilization of ex situ machine perfusion and thoracoabdominalNRP (TANRP) in the United States. Materials and Methods

Keywords: machine perfusion; transplantation; perfusion; situ machine; liver transplantation; united states

Journal Title: Liver Transplantation
Year Published: 2022

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