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Silk fibroin crosslinked glycyrrhizic acid and silver hydrogels for accelerated bacteria-infected wound healing.

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Antibacterial hydrogels have been intensively studied as wound dressings. Silk fibroin (SF) was chemical crosslinked to glycyrrhizic acid (GA) and silver to fabricate a hydrogel dressing with both antibacterial and… Click to show full abstract

Antibacterial hydrogels have been intensively studied as wound dressings. Silk fibroin (SF) was chemical crosslinked to glycyrrhizic acid (GA) and silver to fabricate a hydrogel dressing with both antibacterial and anti-inflammatory properties. The SF/Ag/GA hydrogel exhibited high water content with acceptable mechanical properties, combined the good biocompatibility and biodegradability of SF, the antibacterial activity of silver, and the anti-inflammatory property of GA, capable to promote tissue regeneration during wound healing process, offering great potential as an alternative for wound dressings. This article is protected by copyright. All rights reserved.

Keywords: silver; silk fibroin; acid silver; wound healing; crosslinked glycyrrhizic; glycyrrhizic acid

Journal Title: Macromolecular bioscience
Year Published: 2021

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