LAUSR

The synthesis of polymeric nanoparticles from a block copolymer based on poly(ethylene glycol) and a polymethacrylate containing the nucleobase analogue 2,6-diacylaminopyridine has been optimized by microfluidics to obtain homogeneous spherical micelles. Loading and delivery properties have been studied using naproxen as a model. The incorporation of a Pd precursor in the polymer organic solution fed into the micromixer allows the preparation of Pd(II) precursor-polymer hybrid systems, and the subsequent reduction with CO lead to the in-situ synthesis of Pd nanosheets inside of the hydrophobic core of the polymeric micelles. This methodology is highly efficient to yield all polymeric nanoparticles loaded with Pd nanosheets as detected by electron microscopy and energy-dispersive X-ray spectroscopy. The cell viability of these Pd nanosheets-containing polymeric nanoparticles has been evaluated using five cell lines, showing a high cytocompatibility at the tested concentrations without detrimental effects in cell membrane and nuclei. Furthermore, the use of these hybrid polymeric nanoparticles as photothermal transductors has been evaluated using NIR as irradiation source, as well as its application in photothermal therapy using different cell lines demonstrating a high efficiency in all cell cultures. This article is protected by copyright. All rights reserved.