LAUSR

Polymer assemblies on the nanoscale represent a powerful toolbox for the design of theranostic systems when combined with both therapeutic compounds and diagnostic reporting ones. Here, we present recent advances in the design of theranostic systems for various diseases, containing - in their architecture - either polymers or polymer assemblies as one of the building blocks. This review encompasses the general principles of polymer self-assembly, from the production of adequate copolymers up to supramolecular assemblies with theranostic functionality. Such polymer nanoassemblies can be further tailored through the incorporation of inorganic nanoparticles to endow them with multifunctional therapeutic and/or diagnostic features. We selected systems that change their architecture or properties in the presence of stimuli, as responsivity to changes in the environment is a key factor for enhancing efficiency. Such theranostic systems are based on the intrinsic properties of copolymers or one of the other components. In addition, we present systems with a more complex architecture, such as multicompartments. Selected systems indicate the advantages of such theranostic approaches and provide a basis for further developments in the field. This article is protected by copyright. All rights reserved.