LAUSR

Cell-based nanotherapy holds great potential to transform diagnosis and treatment patterns for human diseases, especially for cardiovascular diseases (CVDs). Surface coating with cell membrane (CM) has become a powerful strategy for functionalization of therapeutic nanoparticles (NPs) to achieve biological performances of superior biocompatibility, immune evasion and specificity. Additionally, extracellular vesicles (EVs) play key roles in the progression of CVDs with their ability of transferring cargos to distant tissues, thus emerging as an appealing option for the diagnosis and therapy of CVDs. In this review, we summarize recent progress in cell-based nanotherapy for CVDs, and highlight different sources of EVs and biomimetic nanoplatforms derived from natural cells. Meanwhile, their promising biomedical applications in the diagnosis and targeted treatment of different CVDs are also provided, followed by a discussion of their potential challenges and future prospects. This article is protected by copyright. All rights reserved.