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Amphiphilic di-block copolymers containing dopamine and zwitterions were synthesized via the RAFT polymerization method which undergo temperature-mediated micellization in aqueous media. The presence of catechol moiety in dopamine was exploited… Click to show full abstract
Amphiphilic di-block copolymers containing dopamine and zwitterions were synthesized via the RAFT polymerization method which undergo temperature-mediated micellization in aqueous media. The presence of catechol moiety in dopamine was exploited to form pH-responsive cross-links with ferric ions (Fe3+ ) at different pH value. Herein, a comprehensive study of the effect of pH as well as temperature on the size and solution behavior of these cross-linked micelles is presented. These micelles crosslinked via metal-catechol coordination bonds could have several important biomedical applications such as degradable scaffolds for payload delivery. This article is protected by copyright. All rights reserved.
Journal Title: Macromolecular rapid communications
Year Published: 2021
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