LAUSR

The use of sequence-defined polymers is an interesting emerging solution for materials identification and traceability. Indeed, a very large amount of identification sequences can be created using a limited alphabet of coded monomers. However, in all reported studies, sequence-defined taggants are usually included in a host material by non-covalent adsorption or entrapment, which may lead to leakage, aggregation or degradation. To avoid these problems, sequence-defined polymers were covalently-attached in the present work to the mesh of model materials, namely acrylamide hydrogels. To do so, sequence-coded polyurethanes containing a disulfide linker and a terminal methacrylamide moiety were synthesized by stepwise solid-phase synthesis. These methacrylamide macromonomers were afterwards copolymerized with acrylamide and bisacrylamide in order to achieve crosslinked hydrogels containing covalently-bound polyurethane taggants. It is shown herein that these taggants can be selectively detached from the hydrogel mesh by reactive desorption electrospray ionization. Using dithiothreitol the disulfide linker that link the taggant to the gel can be selectively cleaved. Ultimately, the released taggants can be decoded by tandem mass spectrometry. This article is protected by copyright. All rights reserved.