LAUSR.org creates dashboard-style pages of related content for over 1.5 million academic articles. Sign Up to like articles & get recommendations!

Targeting proprotein convertases in furin‐rich lung cancer cells results in decreased in vitro and in vivo growth

Photo by s_tsuchiya from unsplash

Proprotein convertases (PCs) are serine proteases with an active role in the post‐translational processing of numerous inactive proteins to active proteins including many substrates of paramount importance in cancer development… Click to show full abstract

Proprotein convertases (PCs) are serine proteases with an active role in the post‐translational processing of numerous inactive proteins to active proteins including many substrates of paramount importance in cancer development and progression. Furin (PCSKC3), a well‐studied member of this family, is overexpressed in numerous human and experimental malignancies. In the present communication, we treated two furin‐overexpressing non‐small cell carcinoma (NSCLC) cell lines (Calu‐6 and HOP‐62) with the PC inhibitor CMK (Decanoyl‐Arg‐Val‐Lys‐Arg‐chloromethylketone). This resulted in a diminished IGF‐1R processing and a simultaneous decrease in cell proliferation of two NSCLC lines. Similarly, growth of subcutaneous xenografts of both cell lines, were partially inhibited by an in vivo treatment with the same drug. These observations point to a potential role of PC inhibitors in cancer therapy. © 2016 Wiley Periodicals, Inc.

Keywords: convertases furin; targeting proprotein; proprotein convertases; cancer; growth

Journal Title: Molecular Carcinogenesis
Year Published: 2017

Link to full text (if available)


Share on Social Media:                               Sign Up to like & get
recommendations!

Related content

More Information              News              Social Media              Video              Recommended



                Click one of the above tabs to view related content.