LAUSR

Clozapine is a unique drug for people with Parkinson ’ s disease (PD). It was the fi rst drug shown to be an effective antipsychotic that did not worsen motor function. 1,2 It was the fi rst drug shown in a double-blind, placebo-controlled trial (DBPCT) to treat any psychiatric symptom in PD. It has strong antitremor properties as well as antidyskinetic effects. However, I will show that it is mark-edly underused because of the lack of US Food and Drug Adminis-tration (FDA) approval for its use in PD, concerns about safety, and the logistics required for blood count monitoring. The next sections discuss how these concerns have been exagerated. Tremor was not studied in the French DBPCT. It has been particularly useful in tremor unresponsive to levodopa. 26 It has been found to be effective for treating levodopa-induced dyskinesias in open trials.