LAUSR

Parkinson ’ s disease (PD) is a neurodegenerative disorder that is characterized clinically by a variety of motor and nonmotor symptoms with debilitating effects on quality of life. Although the disease is gradually progressive, symptoms vary from day to day, which signi fi cantly in fl uences daily functioning. 1 Variations across consecutive days are likely attributable to contextual factors of daily life, such as changes in physical activity, sleep, stress, or diet. 2,3 Anecdotal evidence is beginning to suggest that environmental factors, such as high-altitude stays or warmer temperatures, may also affect symptom severity in people with PD (PwP). However, the in fl uence of such environmental factors has thus far not been stud-ied systematically. A better understanding of how contextual factors drive variations in symptom severity might offer new therapeutic perspectives and could facilitate personalized counseling. To quantify and clarify the in fl uence of contextual factors on PD