LAUSR

Corticobasal syndrome (CBS) is a neurodegenerative condition characterized by cortical and extrapyramidal dysfunction. It can manifest as painful asymmetric rigidity, spasticity, and dystonia. Treatments include muscle relaxants, analgesics, chemodenervation, and physical therapy. 1 Some patient ’ s pain is not alleviated by current treatments, demonstrating the need for new effective treatments. We report what may be the fi rst case of CBS pain treated with stellate ganglion blockade. Stellate ganglion block is used to treat sympathetically mediated pain and complex regional pain syndrome (CRPS) of the upper extremity. We present a 63-year-old female diagnosed with CBS. Six years prior, she developed clumsiness, cramping, and dif fi culty completing tasks involving the right hand. This progressed to severe right upper extremity rigidity after 2 years. She was evaluated by movement and behavioral neurologists. She exhibited right upper extremity akinesis and rigidity, right sided predominate bradykinesia and leg rigidity, de fi cits with attention, language and recall, and speech apraxia. Mag-netic resonance imaging, positron emission tomography, and dopa-mine transporter scan revealed volume loss of the left frontal and anterior parietal lobes, hypometabolism in the left posterior frontal region and mid-cingulate regions, and decreased radiotracer binding in the bilateral putamen, greater on the left. Laboratory studies including a frontotemporal dementia panel were unremarkable.