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Dengue Fever Associated Opsoclonus Myoclonus Ataxia Syndrome

Opsoclonus Myoclonus Ataxia Syndrome (OMAS) is a constellation of symptoms encompassing opsoclonus, myoclonus and ataxia. 1 Here we present, an adult onset OMAS following dengue viral fever. A 39-year-old male… Click to show full abstract

Opsoclonus Myoclonus Ataxia Syndrome (OMAS) is a constellation of symptoms encompassing opsoclonus, myoclonus and ataxia. 1 Here we present, an adult onset OMAS following dengue viral fever. A 39-year-old male patient with no comorbidities presented with acute onset high grade fever and generalized body ache for last two weeks. He tested positive for dengue non-structural protein 1 (NS1) on the 5th day of his illness. Fever subsided on the 9th day of illness. Two days after subsidence of fever, he noted acute onset tremulousness, while approaching an object with either hand. There was a progressive worsening of tremulousness and subsequently he developed swaying to either side while walking. Over the next few days, he was unable to stand or sit by himself due to severe truncal imbalance; and also developed head titubation along with ataxic dysarthria. Abnormal intermittent involuntary jerks affecting all the four limbs, trunk and face were noticed thereafter. Relatives mentioned that his eyes were jerky and he failed to open his eyes due to these jerky movement. There was no history of any tonic clonic limb movements or loss of consciousness.

Keywords: dengue; myoclonus ataxia; ataxia syndrome; opsoclonus myoclonus; fever

Journal Title: Movement Disorders Clinical Practice
Year Published: 2024

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