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PD patients treated with STN-DBS and LCIG, worsening activities of daily living by threefold after adjusting for cognitive impairment, age, and motor severity. Importantly, both symptomatic and asymptomatic orthostatic hypotension… Click to show full abstract
PD patients treated with STN-DBS and LCIG, worsening activities of daily living by threefold after adjusting for cognitive impairment, age, and motor severity. Importantly, both symptomatic and asymptomatic orthostatic hypotension impaired ADL/iADL to a similar extent. Although the results of this cross-sectional study need to be confirmed in prospective clinical trials evaluating patients before and after STN-DBS/LCIG, we suggest that identifying and managing autonomic targets, in addition to addressing motor disability, may enhance outcomes of these advanced PD therapies.
Journal Title: Movement Disorders
Year Published: 2017
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