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Leucine‐rich repeat kinase 2 is a potential therapeutic target for the treatment of Parkinson's disease, and clinical trials of leucine‐rich repeat kinase 2 inhibitors are in development. The objective of… Click to show full abstract
Leucine‐rich repeat kinase 2 is a potential therapeutic target for the treatment of Parkinson's disease, and clinical trials of leucine‐rich repeat kinase 2 inhibitors are in development. The objective of this study was to evaluate phosphorylation of a new leucine‐rich repeat kinase 2 substrate, Rab10, for potential use as a target engagement biomarker and/or patient enrichment biomarker for leucine‐rich repeat kinase 2 inhibitor clinical trials.
Keywords:
parkinson disease;
rich repeat;
repeat kinase;
leucine rich
Journal Title: Movement Disorders
Year Published: 2019
Link to full text (if available)
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Journal Title: Movement Disorders
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!