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Pro‐Saccades Predict Cognitive Decline in Parkinson's Disease: ICICLE‐PD

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Cumulative dementia incidence in Parkinson's disease (PD) is significant, with major personal and socioeconomic impacts on individuals with PD and their carers. Early identification of dementia risk is vital to… Click to show full abstract

Cumulative dementia incidence in Parkinson's disease (PD) is significant, with major personal and socioeconomic impacts on individuals with PD and their carers. Early identification of dementia risk is vital to ensuring optimal intervention. Saccadic deficits often distinguish neurodegenerative disorders and cognitive impairment, but their ability to predict cognitive decline in PD has yet to be determined. The aims of this study were to (1) evaluate baseline (6.4 ± 6.1 months since PD diagnosis) differences in pro‐saccadic metrics between those with early PD and healthy age‐matched adults; and (2) assess the ability of baseline pro‐saccades to predict subsequent cognitive decline over 4.5 years.

Keywords: predict cognitive; saccades predict; decline; pro saccades; parkinson disease; cognitive decline

Journal Title: Movement Disorders
Year Published: 2019

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