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Relationship of Cerebrospinal Fluid Vitamin B12 Status Markers With Parkinson's Disease Progression

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Using blood specimens from untreated early Parkinson's disease (PD) patients from the DATATOP trial, we found that subjects in the low serum vitamin B12 tertile experienced greater annualized change in… Click to show full abstract

Using blood specimens from untreated early Parkinson's disease (PD) patients from the DATATOP trial, we found that subjects in the low serum vitamin B12 tertile experienced greater annualized change in ambulatory capacity score, whereas those with moderately elevated (>15 μmol/L) total homocysteine had greater annualized declines in the Mini‐Mental State Exam.

Keywords: cerebrospinal fluid; relationship cerebrospinal; vitamin b12; parkinson disease

Journal Title: Movement Disorders
Year Published: 2020

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