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Nonsteroidal Anti‐inflammatory Use and LRRK2 Parkinson's Disease Penetrance

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The penetrance of leucine rich repeat kinase 2 (LRRK2) mutations is incomplete and may be influenced by environmental and/or other genetic factors. Nonsteroidal anti‐inflammatory drugs (NSAIDs) are known to reduce… Click to show full abstract

The penetrance of leucine rich repeat kinase 2 (LRRK2) mutations is incomplete and may be influenced by environmental and/or other genetic factors. Nonsteroidal anti‐inflammatory drugs (NSAIDs) are known to reduce inflammation and may lower Parkinson's disease (PD) risk, but their role in LRRK2‐associated PD is unknown.

Keywords: nonsteroidal anti; parkinson disease; penetrance; anti inflammatory

Journal Title: Movement Disorders
Year Published: 2020

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