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VPS35 is part of the retromer complex and is responsible for the trafficking and recycling of proteins implicated in autophagy and lysosomal degradation, but also takes part in the degradation… Click to show full abstract
VPS35 is part of the retromer complex and is responsible for the trafficking and recycling of proteins implicated in autophagy and lysosomal degradation, but also takes part in the degradation of mitochondrial proteins via mitochondria‐derived vesicles. The p.D620N mutation of VPS35 causes an autosomal‐dominant form of Parkinson's disease (PD), clinically representing typical PD.
Keywords:
impairment d620n;
mitochondrial clearance;
vps35 patient;
clearance impairment;
d620n vps35;
patient derived
Journal Title: Movement Disorders
Year Published: 2020
Link to full text (if available)
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Journal Title: Movement Disorders
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!