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A.J.N. reports grants from the Barts Charity, Parkinson’s UK, Cure Parkinson’s, Alchemab, Aligning Science Across Parkinson’s and The Michael J. Fox Foundation, and the Virginia Kieley Benefaction and personal fees/consultancy from Astra Zeneca, Britannia, BIAL, AbbVie, uMed, Alchemab, Charco Neurotech, Biogen, Roche, and UCB outside of the submitted work. R.D. works within the Preventive Neurology Unit, which is funded by the Barts Charity. She receives grant support from the UK MS Society, BMA Foundation, NIHR, MRC, NMSS, Horne Family Charitable Trust, Biogen, Celgene, and Merck. She has received honoraria for advisory boards and/or educational activities from Biogen, Teva, Sanofi, Merck, Janssen, Novartis, and Roche.