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Mitochondrial dysfunction within neurons, particularly those of the substantia nigra, has been well characterized in Parkinson's disease and is considered to be related to the pathogenesis of this disorder. Dysfunction… Click to show full abstract
Mitochondrial dysfunction within neurons, particularly those of the substantia nigra, has been well characterized in Parkinson's disease and is considered to be related to the pathogenesis of this disorder. Dysfunction within this important organelle has been suggested to impair neuronal communication and survival; however, the reliance of astrocytes on mitochondria and the impact of their dysfunction on this essential cell type are less well characterized.
Keywords:
oxidative phosphorylation;
astrocytic changes;
mitochondrial oxidative;
disease;
parkinson disease;
changes mitochondrial
Journal Title: Movement Disorders
Year Published: 2021
Link to full text (if available)
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Journal Title: Movement Disorders
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!