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Use of Glycolysis‐Enhancing Drugs and Risk of Parkinson's Disease

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Terazosin (TZ) and closely related α1‐adrenergic receptor antagonists (doxazosin [DZ] and alfuzosin [AZ]) enhance glycolysis and reduce neurodegeneration in animal models. Observational evidence in humans from several databases supports this… Click to show full abstract

Terazosin (TZ) and closely related α1‐adrenergic receptor antagonists (doxazosin [DZ] and alfuzosin [AZ]) enhance glycolysis and reduce neurodegeneration in animal models. Observational evidence in humans from several databases supports this finding; however, a recent study has suggested that tamsulosin, the comparator medication, increases the risk of Parkinson's disease.

Keywords: use glycolysis; risk parkinson; parkinson disease; glycolysis enhancing

Journal Title: Movement Disorders
Year Published: 2022

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