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GBA1 mutation is the most common genetic risk factor for Parkinson's disease (PD). Replacement of the lysosomal enzyme glucocerebrosidase (GCase) slows neurodegeneration in PD models and may be a promising… Click to show full abstract
GBA1 mutation is the most common genetic risk factor for Parkinson's disease (PD). Replacement of the lysosomal enzyme glucocerebrosidase (GCase) slows neurodegeneration in PD models and may be a promising disease‐modifying therapy in patients with PD. However, recombinant GCase has limited penetration through the blood–brain barrier (BBB). Microbubble‐mediated magnetic resonance–guided focused ultrasound (MRgFUS) can reversibly disrupt the BBB for drug delivery.
Keywords:
magnetic resonance;
guided focused;
focused ultrasound;
disease;
parkinson disease;
resonance guided
Journal Title: Movement Disorders
Year Published: 2022
Link to full text (if available)
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Journal Title: Movement Disorders
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!