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Specific Gait Changes in Prodromal Hereditary Spastic Paraplegia Type 4: preSPG4 Study

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In hereditary spastic paraplegia type 4 (SPG4), subclinical gait changes might occur years before patients realize gait disturbances. The prodromal phase of neurodegenerative disease is of particular interest to halt… Click to show full abstract

In hereditary spastic paraplegia type 4 (SPG4), subclinical gait changes might occur years before patients realize gait disturbances. The prodromal phase of neurodegenerative disease is of particular interest to halt disease progression by future interventions before impairment has manifested.

Keywords: spastic paraplegia; hereditary spastic; paraplegia type; gait changes

Journal Title: Movement Disorders
Year Published: 2022

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