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Cortical Effects of Dopamine Replacement Account for Clinical Response Variability in Parkinson's Disease

Individual variability in clinical response to dopamine replacement therapy (DRT) is a key barrier to efficacious treatment for patients with Parkinson's disease (PD). A better understanding of the neurobiological sources… Click to show full abstract

Individual variability in clinical response to dopamine replacement therapy (DRT) is a key barrier to efficacious treatment for patients with Parkinson's disease (PD). A better understanding of the neurobiological sources of such interindividual differences is necessary to personalize DRT prescribing, inform future clinical interventions, and motivate translational research.

Keywords: clinical response; variability; parkinson disease; dopamine replacement

Journal Title: Movement Disorders
Year Published: 2024

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