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Identification of histone malonylation in the human fetal brain and implications for diabetes‐induced neural tube defects

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Neural tube defects (NTDs) are severe congenital malformations. Diabetes during pregnancy is a risk factor for NTDs, but its mechanism remains elusive. Emerging evidence suggests that protein malonylation is involved… Click to show full abstract

Neural tube defects (NTDs) are severe congenital malformations. Diabetes during pregnancy is a risk factor for NTDs, but its mechanism remains elusive. Emerging evidence suggests that protein malonylation is involved in diabetes. Here, we report the correlation between histone lysine malonylation in diabetes‐induced NTDs.

Keywords: malonylation; tube defects; neural tube; identification histone; diabetes induced

Journal Title: Molecular Genetics & Genomic Medicine
Year Published: 2020

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