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Effect of KRAS mutations and p53 expression on the postoperative prognosis of patients with colorectal cancer

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In the occurrence and development of colorectal cancer, p53 is an important regulator downstream of the MAPK signaling pathway and plays an important role in inhibiting abnormal proliferation signals generated… Click to show full abstract

In the occurrence and development of colorectal cancer, p53 is an important regulator downstream of the MAPK signaling pathway and plays an important role in inhibiting abnormal proliferation signals generated by KRAS mutations. The purpose of this study is to explore the correlation between KRAS mutations and p53 expression and evaluate their prognosis values in colorectal cancer.

Keywords: kras mutations; p53 expression; colorectal cancer; mutations p53

Journal Title: Molecular Genetics & Genomic Medicine
Year Published: 2022

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