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Haplotype‐dependent HLA‐DRB1‐DQB1 susceptibility to occult HBV infection in Xi'an Han population

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Occult hepatitis B virus (HBV) infection (OBI) is primarily characterized by the persistence of HBV‐DNA in the liver tissues and/or in the serum without detectable HBsAg. Human leukocyte antigen (HLA)… Click to show full abstract

Occult hepatitis B virus (HBV) infection (OBI) is primarily characterized by the persistence of HBV‐DNA in the liver tissues and/or in the serum without detectable HBsAg. Human leukocyte antigen (HLA) polymorphisms have been found to be strongly associated with HBV in different ethnic backgrounds. The association of HLA‐DRB1‐DQB1 haplotypes with OBI has not been previously reported in China. The aim of this study was to identify the potential association of HLA‐DRB1‐DQB1 haplotypes that may be involved in OBI genetic susceptibility.

Keywords: hbv infection; drb1 dqb1; hla drb1; hla

Journal Title: Molecular Genetics & Genomic Medicine
Year Published: 2023

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