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Upregulation of miR‐200a and miR‐204 in MPP+‐treated differentiated PC12 cells as a model of Parkinson’s disease

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Parkinson's disease (PD) is ranked as the second most common neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra. Micro(mi)RNAs are a class of small noncoding RNAs… Click to show full abstract

Parkinson's disease (PD) is ranked as the second most common neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra. Micro(mi)RNAs are a class of small noncoding RNAs that regulate gene expression and aberrant expression of them is closely correlated with many neurodegenerative conditions including PD. Silent information regulator 1 (SIRT1) as a known deacetylase and B‐cell lymphoma‐2 (BCL2) as an antiapoptotic factor play vital roles in neural protection and survival.

Keywords: 200a mir; upregulation mir; disease; parkinson disease; mir 204; mir 200a

Journal Title: Molecular Genetics & Genomic Medicine
Year Published: 2019

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