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HDAC4 mutations cause diabetes and induce β‐cell FoxO1 nuclear exclusion

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Studying patients with rare Mendelian diabetes has uncovered molecular mechanisms regulating β‐cell pathophysiology. Previous studies have shown that Class IIa histone deacetylases (HDAC4, 5, 7, and 9) modulate mammalian pancreatic… Click to show full abstract

Studying patients with rare Mendelian diabetes has uncovered molecular mechanisms regulating β‐cell pathophysiology. Previous studies have shown that Class IIa histone deacetylases (HDAC4, 5, 7, and 9) modulate mammalian pancreatic endocrine cell function and glucose homeostasis.

Keywords: diabetes induce; cause diabetes; induce cell; hdac4 mutations; mutations cause; cell

Journal Title: Molecular Genetics & Genomic Medicine
Year Published: 2019

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