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Voxel-based dosimetry is superior to mean-absorbed dose approach for establishing dose-effect relationship in targeted radionuclide therapy.

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It is becoming evident that patient-individualized dosimetry in targeted radionuclide therapy (TRT) is a must and not a luxury in the era of precision medicine. It's often argued that patient-specific… Click to show full abstract

It is becoming evident that patient-individualized dosimetry in targeted radionuclide therapy (TRT) is a must and not a luxury in the era of precision medicine. It's often argued that patient-specific absorbed dose assessment should be the standard and become routine in TRT, similar to other forms of radiation therapy to improve the correlations between the administered activitiy and the clinical outcome and enable better understanding of the absorbed dose-response relationship.

Keywords: radionuclide therapy; relationship; dosimetry; absorbed dose; therapy; targeted radionuclide

Journal Title: Medical physics
Year Published: 2019

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