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PURPOSE The goals of this study include: (a) generating tailored magnetic resonance fingerprinting (TMRF) based non-synthetic imaging; (b) assessing the repeatability of TMRF and deep learning-based mapping of in vitro ISMRM/NIST phantom and in vivo brain data of healthy human subjects. METHODS We have acquired qualitative images obtained from the vendor-supplied gold standard, MRF (synthetic), and TMRF (non-synthetic) on one representative healthy human brain. We also acquired thirty datasets on the ISMRM/NIST phantom for the in vitro repeatability study on a GE Discovery 3T MR750w scanner using the TMRF sequence. We compared T1 and T2 maps generated from thirty ISMRM/NIST phantom datasets to the spin-echo (SE) based gold standard (GS) method as part of the in vitro repeatability study. R-squared coefficient of determination in a simple linear regression and Bland-Altman analysis were computed for thirty datasets of ISMRM/NIST phantom to assess the accuracy of in vitro quantitative TMRF data. The repeatability of T1 and T2 estimates by TMRF was evaluated by calculating the standard deviation (SD) divided by the average of thirty datasets for each sphere, respectively. We acquired ten volunteers for the in vivo repeatability study on the same scanner using the same TMRF sequence. These volunteers were imaged five times with two runs per repetition, resulting in one hundred in vivo datasets. Five contrasts, T1 and T2 maps of ten human volunteers acquired over five repetitions, were evaluated in the in vivo repeatability study. We computed the intraclass correlation coefficient (ICC) of the signal-to-noise ratio (SNR), signal intensities, T1 and T2 relaxation times in white matter (WM) and gray matter (GM). RESULTS The synthetic images generated from MRF show partial volume and flow artifacts compared to non-synthetic images obtained from TMRF images and the gold standard. in vitro studies show that TMRF estimates have less than 5% variations except sphere 14 in the T2 array (6.36%). TMRF and spin-echo relaxometry measurements were strongly correlated; R2 values were 0.9958 and 0.9789 for T1 and T2 estimates, respectively. Based on the ICC values, SNR, mean intensity values, and relaxation times of WM and GM for the in vivo studies were consistent. T1 and T2 values of WM and GM were similar to previously published values. The mean ± SD of T1 and T2 for WM for ten subjects and five repeats are 992 ± 41 ms and 99 ± 6 ms, while the corresponding values for T1 and T2 for GM are 1598 ± 73 ms and 152 ± 14 ms. CONCLUSION TMRF and deep learning-based reconstruction produce repeatable, non-synthetic multi-contrast images and parametric maps simultaneously. This article is protected by copyright. All rights reserved.