LAUSR

PURPOSE To develop a deep neural network for accelerating magnetic resonance elastography (MRE) acquisition, to validate the ability to generate reliable MRE results with the down-sampled k-space data, and to demonstrate the feasibility of the proposed method in monitoring the stiffness changes during thermal ablation in a phantom study. MATERIALS AND METHODS MRE scans were performed with 60 Hz excitation on porcine ex-vivo liver gel phantoms in a 0.36T MRI scanner to generate the training dataset. The acquisition protocol was based on a spin-echo MRE pulse sequence with tailored motion-sensitive gradients to reduce echo time (TE). A U-Net based deep neural network was developed and trained to interpolate the missing data from down-sampled k-space. We calculated the errors of 80 sets magnitude/phase images reconstructed from the zero-filled, compressive sensing (CS) and deep learning (DL) method for comparison. The peak signal-to-noise rate (PSNR) and structural similarity (SSIM) of the magnitude/phase images were also calculated for comparison. The stiffness changes were recorded before, during, and after ablation. The mean stiffness values over the region of interest (ROI) were compared between the elastograms reconstructed from the fully-sampled k-space and interpolated k-space after thermal ablation. RESULTS The mean absolute error (MAE), PSNR, and SSIM of the proposed deep learning approach were significantly better than the results from the zero-filled method (p<0.0001) and CS (p<0.0001). The stiffness changes before and after thermal ablation assessed by the proposed approach (before: 7.7±1.1 kPa, after: 11.9±4.0 kPa, 4.2-kPa increase) gave close agreement with the values calculated from the fully-sampled data (before: 8.0±1.0 kPa, after: 12.6±4.2 kPa, 4.6-kPa increase). In contrast, the stiffness changes computed from the zero-filled method (before: 4.9±1.4 kPa, after: 5.6±2.8 kPa, 0.7-kPa increase) were substantially underestimated. CONCLUSION This study demonstrated the capability of the proposed deep learning method for rapid MRE acquisition and provided a promising solution for monitoring the MRI-guided thermal ablation. This article is protected by copyright. All rights reserved.