LAUSR

BACKGROUND Using the spin-lattice relaxation time (T1) as a biomarker, the myocardium can be quantitatively characterized using cardiac T1 mapping. The modified Look-Locker inversion recovery (MOLLI) sequences have become the standard clinical method for cardiac T1 mapping. However, the MOLLI sequences require an 11-heartbeat breath-hold that can be difficult for subjects, particularly during exercise or pharmacologically induced stress. Although shorter cardiac T1 mapping sequences have been proposed, these methods suffer from reduced precision. As such, there is an unmet need for accelerated cardiac T1 mapping. PURPOSE To accelerate cardiac T1 mapping MOLLI sequences by using neural networks to estimate T1 maps using a reduced number of T1-weighted images and their corresponding inversion times. MATERIALS AND METHODS In this retrospective study, 911 pre-contrast T1 mapping datasets from 202 subjects (128 males, years; 74 females, years) and 574 T1 mapping post-contrast datasets from 193 subjects (122 males, years; 71 females, years) were acquired using the MOLLI-5(3)3 sequence and the MOLLI-4(1)3(1)2 sequence respectively. All acquisition protocols used similar scan parameters: and gadoteridol (ProHance, Bracco Diagnostics) dose. A bidirectional multi-layered long short-term memory (LSTM) network with fully connected output and cyclic model-based loss was used to estimate T1 maps from the first three T1-weighted images and their corresponding inversion times for pre-contrast and post-contrast T1 mapping. The performance of the proposed architecture was compared to the three-parameter T1 recovery model using the same reduction of the number of T1-weighted images and inversion times. Reference T1 maps were generated from the scanner using the full MOLLI sequences and the three-parameter T1 recovery model. Correlation and Bland-Altman plots were used to evaluate network performance where each point represents averaged regions of interest in the myocardium corresponding to the standard American Heart Association 16-segment model. The precision of the network was examined using consecutively repeated scans. Stress and rest pre-contrast MOLLI studies as well as various disease test cases including amyloidosis, hypertrophic cardiomyopathy, and sarcoidosis were also examined. Paired t-tests were used to determine statistical significance with. RESULTS Our proposed network demonstrated similar T1 estimations to the standard MOLLI sequences (pre-contrast: vs. with post-contrast: vs. with). The precision of standard MOLLI sequences was well preserved with the proposed network architecture. Network-generated T1 reactivities are similar to stress and rest pre-contrast MOLLI studies. Amyloidosis T1 maps generated using the proposed network are also similar to the reference. CONCLUSIONS A bidirectional multi-layered LSTM network with fully connected output and cyclic model-based loss was used to generate high-quality pre-contrast and post-contrast T1 maps using the first three T1-weighted images and their corresponding inversion times. This work demonstrates that combining deep learning with cardiac T1 mapping can potentially accelerate standard MOLLI sequences from 11 heartbeats to 3 heartbeats. This article is protected by copyright. All rights reserved.