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BACKGROUND Dedicated cone-beam breast computed tomography (CBBCT) using short-scan acquisition is being actively investigated to potentially reduce the radiation dose to the breast. This would require determining the optimal x-ray source trajectory for such short-scan acquisition. PURPOSE To quantify the projection angle-dependent normalized glandular dose coefficient ( D g N C T $Dg{N}^{CT}$ ) in CBBCT, referred to as angular D g N C T $Dg{N}^{CT}$ , so that the x-ray ray source trajectory that minimizes the radiation dose to the breast for short-scan acquisition can be determined. MATERIALS AND METHODS A cohort of 75 CBBCT clinical datasets was segmented and used to generate three breast models - (I) patient-specific breast with heterogeneous fibroglandular tissue distribution and real breast shape, (II) patient-specific breast shape with homogeneous tissue distribution and matched fibroglandular weight fraction, and (III) homogeneous semi-ellipsoidal breast with patient-specific breast dimensions and matched fibroglandular weight fraction, which corresponds to the breast model used in current radiation dosimetry protocols. For each clinical dataset, the angular D g N C T $Dg{N}^{CT}$ was obtained at 10 discrete angles, spaced 36° apart, for full-scan, circular, x-ray source trajectory from Monte Carlo simulations. Model III is used for validating the Monte Carlo simulation results. Models II and III are used to determine if breast shape contributes to the observed trends in angular D g N C T $Dg{N}^{CT}$ . A geometry-based theory in conjunction with center-of-mass ( C O M $COM$ ) based distribution analysis is used to explain the projection angle-dependent variation in angular D g N C T $Dg{N}^{CT}$ . RESULTS The theoretical model predicted that the angular D g N C T $Dg{N}^{CT}$ will follow a sinusoidal pattern and the amplitude of the sinusoid increases when the center-of-mass of fibroglandular tissue ( C O M f $CO{M}_f$ ) is farther from the center-of-mass of the breast ( C O M b $CO{M}_b$ ). It also predicted that the angular D g N C T $Dg{N}^{CT}$ will be minimized at x-ray source positions complementary to the C O M f $CO{M}_f$ . The C O M f $CO{M}_f$ was superior to the C O M b $CO{M}_b$ in 80% (60/75) of the breasts. From Monte Carlo simulations and for homogeneous breasts (models II and III), the deviation in breast shape from a semi-ellipsoid had minimal effect on angular D g N C T $Dg{N}^{CT}$ and showed less than 4% variation. From Monte Carlo simulations and for model I, as predicted by our theory, the angular D g N C T $Dg{N}^{CT}$ followed a sinusoidal pattern with maxima and minima at x-ray source positions superior and inferior to the breast, respectively. For model I, the projection angle-dependent variation in angular D g N C T $Dg{N}^{CT}$ was 16.4%. CONCLUSION The heterogeneous tissue distribution affected the angular D g N C T $Dg{N}^{CT}$ more than the breast shape. For model I, the angular D g N C T $Dg{N}^{CT}$ was lowest when the x-ray source was inferior to the breast. Hence, for short-scan CBBCT acquisition with C O M b $CO{M}_b$ aligned with axis-of-rotation, an x-ray source trajectory inferior to the breast is preferable and such an acquisition spanning 205° can potentially reduce the mean glandular dose by up to 52%. This article is protected by copyright. All rights reserved.